George seeks refuge at Bellevue Hospital, a Manhattan intake center for homeless men, where his friendship with a fellow client helps him try to repair his relationship with his estranged daughter.

Star Wars fanatics take a cross-country trip to George Lucas ' Skywalker Ranch so their dying friend can see a screening of Star Wars: Episode I - Die dunkle Bedrohung (1999) before its release.

Just before he's to marry Fiona, Roderick Blank receives an anonymous e-mail with 101 names on it; Fiona's is the 29th, the first 28 are women Rod has slept with, and the 30th turns out to be the stripper at his bachelor party. The notion that he will have sex with 70 more people sends Rod into crisis mode, especially after three odd men in an aseptic office confirm that a celestial machine has made an error. They suggest destroying the list, but Rod finds that easier said than done. Working his way through it consumes him, plus he realizes that death may await him after #101. Meanwhile, a femme fatale nicknamed Death Nell is putting men into a coma. Are they fated to meet?